Pancreatitis associated with valproic acid therapy for epilepsy.
نویسندگان
چکیده
Valproic acid is useful for absence, myoclonic, and grand ma1 seizures and adjunctively for mixed seizures [31. The drug has been well tolerated in most patients, but vomiting, rashes, hair loss, leukopenia, and thrombocytopenia have been observed. Seven patients have developed hepatitis, which was fatal in 6 151. We recently treated a child who developed pancreatitis in direct association with valproic acid therapy.
منابع مشابه
Valproic acid-associated pancreatitis: report of three cases and a brief review.
We describe three patients with seizure disorders in whom pancreatitis or pancreatic injury was probably caused by valproic acid, a widely used anticonvulsant drug. Trivial or no increases of serum amylase (EC 3.2.1.1) but striking increases of serum lipase (EC 3.1.1.3) were common to all patients, as assayed in the Kodak Ektachem. In vitro, valproic acid does not cause any change in serum lipa...
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Valproic acid (VPA) is a commonly prescribed and approved treatment for epilepsy, including Angelman syndrome, throughout the world. However, the long-term administration of drugs like VPA is associated with the possible development of gastric varices and splenic obstruction as a result of chronic pancreatitis. Such cases can be difficult to treat using endoscopy or interventional radiology bec...
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Neuropediatrician, Pediatrics Service of the Hospital “Felipe Guevara Rojas”, El Tigre-Anzoátegui, Venezuela; Pediatrician, Electroencephalographer, Epilepsy and Encephalography Unit,Clinical Center “Esperanza Paraco”, El Tigre-Anzoátegui, Venezuela; Pediatrics Resident, Pediatrics Service of the Hospital “Felipe Guevara Rojas “, El Tigre-Anzoátegui, Venezuela; Pediatrician, Pediatrics Service ...
متن کاملValproate associated acute pancreatitis.
There is a definitive association between valproate therapy and acute pancreatitis. More than 50 cases have been reported. Most of the reported cases were mild yet there were a few more cases with higher morbidity and mortality. The risk is higher in patients under 20 years of age, during the first year of therapy, on the patient having encephalopathy or chronic renal failure and on patients wi...
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عنوان ژورنال:
- Annals of neurology
دوره 7 1 شماره
صفحات -
تاریخ انتشار 1980